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Fig. 7 | Cancer Cell International

Fig. 7

From: FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway

Fig. 7

FAP activates the PI3K/AKT/mTOR pathway in vitro. A–E BEZ235, a dual PI3K/mTOR inhibitor, attenuated the FAP overexpression-induced proliferation, migration and invasion of ccRCC cells, as evidenced by the CCK-8 assays A, flow cytometry assays B, wound-healing assays C, transwell migration assays D and transwell invasion assays E. F The increases in the protein levels of p-PI3K, p-AKT, and p-mTOR after FAP overexpression were markedly attenuated by BEZ235 treatment. #p < 0.05 vs. the FAP OE group

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Cancer Cell International

ISSN: 1475-2867

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