Fig. 2

Classification of methylation-based research techniques. The cutting-edge research techniques for studying methylation can be categorized into two groups: genome-wide methylomics and site-specific methylation detection. The genome-wide group mainly includes RRBS, WGBS, hMeDIP-seq, MeRIP-seq, and Single-cell methylation sequencing. The site-specific group comprises profiling methods of qMSP, MeRIP-qPCR, and ChIP-qPCR. The input sample type and the schematic of each novel technique are illustrated in the graph