Table 1 Characteristics of “artificial” methylation for the6rapeutics and research
Methods | Methylation modification | Function | Conclusion | References |
|---|---|---|---|---|
CRISPRoff/on | Addition/removal of methyl group |
| • Gene-editing technology, manipulating the methylation landscape • Silencing/activating gene expression • High specificity and durable, long-term, and heritable genetic effects • Anti-tumor/potential therapeutic effects and treatments of neurodegenerative diseases | |
Methylation-targeted agents (MTA) | Deletion of methyl group |
| • 5-Azacytidine and decitabine to treat MDS and AML • Combination treatment with the DNMTi and SGI-110, suggesting strong clinical potential for preventing the recurrence of ovarian cancer • Bidirectional targeting of histone methylation: tazemetostat for treating metastatic or advanced epithelioid sarcoma; CC-90011 for advanced solid tumors or relapsed/refractory marginal zone lymphoma |
