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Fig. 2 | Cancer Cell International

Fig. 2

From: Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

Fig. 2

Functional enrichment analysis in TARGET cohort. A A circle graph showing the results of GO and KEGG enrichment analysis. Red nodes: Up-regulated in high expression of DIO3OS groups; Blue nodes: Down-regulated in high expression of DIO3OS groups. The blue or red color of the Z-score represents the activated or suppressed pathways in functional enrichment analysis. Red: Activated pathway; Blue: Suppressed pathway. B A chord plot showing the results of GO and KEGG enrichment analysis. The blue or red color of the LogFC represents gene expression between samples. Red: Up-regulated; Blue: Down-regulated. C A function enrichment network. Red nodes: genes; Blue Nodes: functional terms. D A bubble plot of GSEA enrichment analysis in TARGET cohort. p < 0.05. E TGF-β signaling pathway was significant enrichment using GSEA enrichment analysis in TARGET cohort

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