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Fig.7 | Cancer Cell International

Fig.7

From: Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

Fig.7

Activating TGF-β signaling pathway reversed si-DIO3OS-induced the attenuation of cell migration, invasion in osteosarcoma cells. A Inhibited DIO3OS expression repressed the activation of TGF-β signaling pathway in SaoS-2 cells. B Inhibited DIO3OS expression repressed the activation of TGF-β signaling pathway in U2OS cells. C TGF-β1 reversed si-DIO3OS-induced the attenuation of TGF-β signaling pathway in SaoS-2 cells. D Activating TGF-β signaling pathway reversed si-DIO3OS-induced the attenuation of cell migration, invasion in SaoS-2 cells using Transwell assays. The scale bar were marked in red, 100 μm. E TGF-β1 revised si-DIO3OS-induced the promoted expression of E-cad and inhibited expression of vimentin in SaoS-2 cells. F Activating TGF-β signaling pathway reversed si-DIO3OS-induced the attenuation of cell migration in SaoS-2 cells using wound healing assay.P-value of less than 0.05 is considered statistically significant (ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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