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Fig. 8 | Cancer Cell International

Fig. 8

From: Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

Fig. 8

The DIO3OS silence inhibited osteosarcoma cell metastasis in vivo. A Images of BALB/C nude mice injected SaoS-2 cell treated with si-NC and si-DIO3OS via tail vein. B Images of lung tissue from BALB/C nude mice injected SaoS-2 cell treated with si-NC and si-DIO3OS via tail vein. C Weight of lung from si-DIO3OS group was significant lower than si-NC group. D Number of metastatic nodules in lung from si-DIO3OS was significant lower than si-NC group. E The expression of DIO3OS in two groups of mice using qRT-PCR. F The expression levels of E-cad were up-regulated in si-DI3OS group. G The expression levels of Vimentin were suppressed in si-DI3OS group. H Western blotting analysis of E-cad, Vimentin, p-SMAD2 and SMAD2 in two groups of mice. P-value of less than 0.05 is considered statistically significant (ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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