Fig. 4

MND1 increases the sensitivity to oxaliplatin in vitro and in vivo. A IC50 curve and optimal dose of oxaliplatin in GC cells. B, C CCK-8 and colony cloning assay were used to detect proliferation in each group. D Annexin V-APC/PI double staining was used to detect apoptosis in each group. E Subcutaneous tumorigenesis was performed in nude mice in each group. F, G Tumor growth curve and tumor weight in nude mice. H The expressions of Ki67, MND1, E-cadherin, N-Carherin and Vimentin were detected by immunohistochemistry in nude mice (*P-value < 0.05, **P-value < 0.01, ***P-value < 0.001). All figures represent mean ± SD from three independent experiments