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Fig. 4 | Cancer Cell International

Fig. 4

From: The MYBL2–CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages

Fig. 4

Impaired macrophage recruitment and tumor growth in vivo upon shMYBL2 of mice with OVC. (A) Workflow of investigation with or without clodronate liposome (LC) treatment. (B) Overall survival (OS) curves were obtained using the Kaplan–Meier method and analyzed using the log-rank test. (C) Tumors from orthotopic syngenetic models with or without LC treatment. Flow cytometry analysis of the proportions of infiltrated CD11b + F4/80 + macrophages (D-E), CD206 + cells in macrophages (F) and the ratio of CD4+/CD8 + T cells in ascites (H). F4/80 (G) and CD8 (I) immunohistochemical staining and quantification in the tumors of Lipo-PBS and Lipo-clodronate-treated mice. (J) Association between the expression of MYBL2 and the ratio of CD8/CD68 by immunohistochemistry

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Cancer Cell International

ISSN: 1475-2867

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