Table 2 The effects of EGCG on microRNAs in various cancers

miR-21, miR-16

In vitro

Breast cancer

Down

Controlling NF-kB

[104]

hsa-miR-204, hsa-miR-222, hsa-miR-21, hsa-miR-146b, hsa-miR-221

In vitro

Thyroid cancer

Up

Improving the apoptosis

[100]

miR-106b, miR-93, miR-92

In vitro

Malignant neuroblastoma

Down

Improving the apoptosis

[105]

miR-99a, miR-34a, miR-7-1

In vitro

Malignant neuroblastoma

Up

Improving the apoptosis

[105]

miR-27, miR-21

In vitro

Breast cancer

Dow

Changes in the miRNA control of possible cancer-causing genes and tumor-suppressing genes

[10]

miR-16

In vivo

Breast cancer

Up

NF-κB pathway

[106]

miR-485

In vivo

Non-small cell lung cancer

Up

Control miR-485/CD44 axis

[107]

hsa-mir-485-5p

In vivo

Non-small cell lung cancer

Up

Control the hsa-mir-485-5p/RXRα axis

[108]

miR483-3p

In vivo

Hepatocellular carcinoma cells

Down

Hypermethylation of the miR483-3p promoter region

[109]

miR-155-5p

In vitro

Colorectal Cancer

Up

Suppressing GRP78/NF-κB/miR-155-5p/MDR1 Pathway

[110]

miR-1226-3p, miR-185-3p, miR-642a-5p, miR-3116, miR-31-5p,

In vitro

Bladder cancer

Up

Modulation Hippo signaling pathway

[111]

hsa-miR-1915 hsa-miR-29b-1-5p hsa-miR-210 hsa-miR-1225-5p

hsa-miR-1202 hsa-miR-1246 hsa-miR-1973

hsa-miR-3162 hsa-miR-4281

hsa-miR-3656

hsa-miR-3665

hsa-miR-1207-5p

hsa-miR-3196

hsa-miR-34a

hsa-miR-2861

In vitro

Nasopharyngeal carcinoma

Up

Apoptosis, Cell cycle, Cell proliferation

[112]

miR-296

In vitro

Nasopharyngeal Carcinoma

Up

Suppressing migratory properties of anoikis-resistant cells

[113]

miR-34a, let-7a

In vitro

Hepatocellular carcinoma

Up

Improving cytotoxicity and inducing the apoptotic pathway

[114]

miR-195

In vitro

Prostate cancer

Up

Affect on EMT

[115]

miR-181a

In vitro

Prostate Cancer

Up

Prompting the cellular apoptosis

[116]

miRNA-21

In vivo

Prostate cancer

Down

Suppressing cells growth and Antagonist of AR signaling and

[117]

miRNA-330

In vivo

Prostate cancer

Up

Suppressing cells growth and antagonist of AR signaling and

[117]

miR-200c, miR-145, miR-34a,

In vitro

Colorectal cancer

Up

Suppressing Notch and Bmi1, Ezh2, and Suz12

[118]

miR-210

In vitro

Lung cancer

Up

Anti-proliferation

[8]

miR-30e-3p

In vitro

Malignant melanoma

Up

Controlling circ_MITF/miR-30e-3p/HDAC2 axis

[119]

microRNA-let-7b

In vitro

Malignant melanoma

Up

Down-modulstion of high mobility group A2 (HMGA2)

[120]

miR-204

In vitro

Oral squamous cell carcinomas

Down

miR204-mediated inhibition of Sox4 and Slug

[121]

miR-25

In vitro

Breast cancer

Down

Anti-proliferation and pro-apoptosis

[9]

let-7

In vitro

Lung cancer

Up

Let-7 signaling pathway

[122]

hsa-miR-98-5p

In vitro

Non-small cell lung cancer

Down

Elevating of p53

[123]

miR-133a/b

In vivo

Prostatic hyperplasia

Down

[124]

miR-203, miR-125b

In vitro

Cervical carcinoma

Down

Induce cell cycle arrest and apoptosis

[99]

miR-29a, miR-210, miR-29, miR-203, miR-125b,

In vitro

Cervical carcinoma

Up

Induce cell cycle arrest and apoptosis

[99]