Fig. 2

Probability of survival and metastasis based on p53 isoform expression in melanoma. Kaplan–Meier plots of metastasis in primary melanomas (n = 46) based on A. cytoplasmic TAp53 H-scores > 12.16 (n = 9) or < 12.16 (n = 37), B. relative nuclear p53β > 1.118 (n = 28) or < 1.118 (n = 19), and C. relative nuclear Δ40p53 > 0.7854 (n = 21) or < 0.7854 (n = 26). Kaplan–Meier plots of melanoma-specific survival in all melanomas (n = 80) based on D. nuclear TAp53 H-scores > 63.04 (n = 23) or < 63.04 (n = 57), E. nuclear p53β H-scores > 48.03 (n = 31) or < 48.03 (n = 49), F. nuclear Δ40p53 H-scores > 47.48 (n = 10) or < 47.48 (n = 70), G. nuclear Δ133p53 H-scores > 20.09 (n = 11) or < 20.09 (n = 69), H. relative nuclear p53β > 1.318 (n = 34) or < 1.318 (n = 46), I. relative Δ40p53 > 0.1942(n = 56) or < 0.1942 (n = 24), J. relative nuclear Δ133p53 > 1.158 (n = 16) or < 1.158 (n = 64), K. cytoplasmic TAp53 H-scores > 38.53 (n = 10) or < 38.53 (n = 70), L. cytoplasmic p53β H-scores > 23.47 (n = 10) or < 23.47 (n = 70), M. cytoplasmic Δ40p53 H-scores > 0.019 (n = 45) or < 0.019 (n = 35), N. cytoplasmic Δ133p53 H-scores > 2.80 (n = 12) or < 2.80 (n = 68), O. relative cytoplasmic p53β > 0.1414 (n = 51) or < 0.1414 (n = 29), P. relative cytoplasmic Δ40p53 > 0.0000928 (n = 43) or < 0.0000928 (n = 37), and Q. relative cytoplasmic Δ133p53 > 1.303 (n = 61) or < 1.303 (n = 19). Significance by Log-rank tests. ns – not significant; *—p < 0.05; **—p < 0.01; ***—p < 0001; ****—p < 0.0001. p-values of ≥ 0.025 did not pass multiple comparison correction (applicable to 2B and 2H)