It is not all about the alpha: elevated expression of p53β variants is associated with lower probability of survival in a retrospective melanoma cohort

Table 1 Spearman’s rho correlation between isoform H-scores or isoform:TAp53 ratios and clinical parameters in primary melanomas

H-scores		TAp53 (DO-1) H-score (nucleus)	TAp53 (DO-1) H-score (cytoplasm)	p53β (KJC8) H-score (nucleus)	p53β (KJC8) H-score (cytoplasm)	Δ133p53 (KJC133) H-score (nucleus)	Δ133p53 (KJC133) H-score (cytoplasm)	Δ40p53 (KJC40) H-score (nucleus)	Δ40p53 (KJC40) H-score (cytoplasm)
Age at Diagnosis	Correlation Coefficient	0.109	0.178	0.031	− 0.045	0.137	− 0.003	0.017	− 0.181
Age at Diagnosis	p-value	0.372	0.144	0.799	0.708	0.255	0.977	0.886	0.131
Stage	Correlation Coefficient	0.448*	0.377	0.185	− 0.005	− 0.024	0.227	− 0.161	− 0.015
Stage	p-value	0.028	0.070	0.376	0.980	0.911	0.275	0.441	0.943
Clarke's Microanatomical Level	Correlation Coefficient	0.293*	0.125	0.015	− 0.047	0.083	0.136	− 0.323*	− 0.155
Clarke's Microanatomical Level	p-value	0.028	0.360	0.911	0.726	0.534	0.308	0.013	0.246
Tumour Thickness (cm)	Correlation Coefficient	0.121	0.030	0.069	0.103	0.203	0.193	− 0.141	− 0.028
Tumour Thickness (cm)	p-value	0.391	0.834	0.619	0.457	0.140	0.161	0.309	0.840

Isoform:TAp53 ratios		p53β:TAp53 (KJC8/DO-1) (nucleus)	p53β:TAp53 (KJC8/DO-1) (cytoplasm)	Δ133p53:TAp53 (KJC133/DO-1) (nucleus)	Δ133p53:TAp53 (KJC133/DO-1) (cytoplasm)	Δ40p53:TAp53 (KJC40/DO-1) (nucleus)	Δ40p53:TAp53 (KJC40/DO-1) (cytoplasm)
Age at diagnosis	Correlation Coefficient	− 0.073	− 0.277*	0.003	− 0.165	− 0.064	− 0.239
Age at diagnosis	p-value	0.552	0.026	0.980	0.193	0.605	0.058
Stage	Correlation Coefficient	− 0.398	− 0.206	− 0.323	− 0.050	− 0.614**	− 0.105
Stage	p-value	0.054	0.347	0.123	0.820	0.001	0.632
Breslow thickness	Correlation Coefficient	− 0.369**	− 0.250	− 0.120	− 0.037	− 0.568***	− 0.255
Breslow thickness	p-value	0.005	0.071	0.380	0.795	< 0.0001	0.065
Clarke's microanatomical level	Correlation Coefficient	− 0.144	− 0.021	0.166	0.125	− 0.232	− 0.113
Clarke's microanatomical level	p-value	0.309	0.887	0.239	0.393	0.101	0.440

Significant correlations ins bold. *—p < 0.05 (did not pass multiple comparison correction); **—p < 0.01; ***—p < 0.0001

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