Table 1 Oncogenic ncRNAs inhibit the KLF2 by PRC2 recruitment
From: PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression
ncRNA | KLF2 regulation | Tumor Type | Samples | KLF2 Function | Clinical Application | Year | Study |
|---|---|---|---|---|---|---|---|
TUG1 | KLF2 down regulation | Hepatocellular carcinoma | 77T 77Â N tissues HepG2, Hep3B, MHCC-97Â H cell lines Nude mice | Tumor suppressor | Diagnosis | 2015 | Huang (15) |
ZFAS1 | KLF2 down regulation | Gastric cancer | 54T 54Â N tissues BGC823, SGC7901, MGC803, AGS, HGC27 cell line Nude mice | Tumor suppressor | Diagnosis | 2017 | Nie (19) |
DLEU1 | KLF2 down regulation | Gastric cancer | 68T 68Â N tissues AGS, SGC7901, MGC803, and BGC823 cell lines | Tumor suppressor | Diagnosis | 2018 | Li (20) |
LINC00202 | KLF2 down regulation | Gastric cancer | 60T 60Â N tissues AGS and SGC-7901 cell lines | Tumor suppressor | Diagnosis | 2021 | Xu (40) |
LINC01296 | KLF2 down regulation | Esophageal squamous cell carcinoma | 78T 78Â N tissues EC109, EC9706, and TE-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Wang (41) |
AFAP1-AS1 | KLF2 down regulation | Gastric cancer | SGC-7901 and AGS cell lines | Tumor suppressor | Diagnosis | 2020 | Yuan (42) |
MiR-32-5p | KLF2 down regulation | Oral squamous cell carcinoma | 30T 30Â N tissues SCC-9, SCC-15, SCC-25, CAL-27, and Tca-8113 cell lines | Tumor suppressor | Diagnosis | 2022 | Qin (47) |
HOXA11-AS | KLF2 down regulation | Gastric cancer | BGC823, SGC7901 and AGS cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Liu (50) |
LINC00460 | KLF2 down regulation | Colorectal cancer | 60T 60Â N tissues HCT116, SW480, HT-29, and Lovo cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Lian (58) |
L22NC03-N64E9.1 | KLF2 down regulation | Colorectal cancer | 50T 50Â N tissue DLD-1, Lovo, HT-29, SW480, SW620, and HCT116 cell line | Tumor suppressor | Diagnosis | 2017 | Lian (59) |
SNHG1 | KLF2 down regulation | Colorectal cancer | 160T 80Â N tissues HCT-116, HCT-8, SW-480, SW-620, DLD-1 and HT-29 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Xu (67) |
HOXA-AS2 | KLF2 down regulation | Colorectal cancer | 69T 69Â N tissues HCT116, DLD1, SW480, SW620, HT-29 and LOVO cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Ding (68) |
miR-25-3p | KLF2 down regulation | Colorectal cancer | 27T 27Â N tissues SW480, LS174T, SW620, LOVO, and HCT116 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Zeng (75) |
LINC01133 | KLF2 down regulation | Non-small cell lung cancer | 68T 68Â N tissues PC9, SPC-A1, NCI-H1975, H1299, and A549 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Zang (83) |
miR-572 | KLF2 down regulation | Non-small cell lung cancer | 46T 46Â N tissues A549, H1299, PC-9, H358, and SPC-A1 cell lines | Tumor suppressor | Diagnosis | 2022 | Sun (85) |
AGAP2-AS1 | KLF2 down regulation | Non-small cell lung cancer | 80T 80Â N tissues A549, PC9, SPCA1, H1975 and H1299 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Li (91) |
LINC00511 | KLF2 down regulation | Non-small cell lung cancer | 57T 57Â N tissues A549, PC9 and H460 cell lines | Tumor suppressor | Diagnosis | 2019 | Zhu (92) |
XIST | KLF2 down regulation | Non-small cell lung cancer | 53T 53Â N tissues A549, SK-MES-1, H1299, 95D, H460, H520, H1975, H157, SK-LU-1, and SPC-A-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Fang (93) |
miR-126-5p | KLF2 up regulation | Lung adenocarcinoma | 78T 78Â N tissues H1975, A549 and H1650 cell lines Nude mice | Tumor suppressor | Diagnosis | 2022 | Han (94) |
FBXL19-AS1 | KLF2 down regulation | Hepatocellular cancer | 60T 60Â N tissues SMMC7721 and HCCLM3 cell lines | Tumor suppressor | Diagnosis | 2021 | Chen (111) |
ANRIL | KLF2 down regulation | Hepatocellular cancer | 77T 77Â N tissues HepG2, Hep3B, and MHCC-97Â H cell lines BALB/c nude mice | Tumor suppressor | Diagnosis | 2015 | Huang (112) |
DUXAP8 | KLF2 down regulation | Hepatocellular carcinoma | HepG2 and Hep3 cell lines | Tumor suppressor | Diagnosis | 2019 | Jiang (113) |
IRAIN | KLF2 down regulation | Pancreatic cancer | 37T 37Â N tissues AsPC-1, BxPC-3, and PANC-1 cell lines | Tumor suppressor | Diagnosis | 2016 | Lian (128) |
SNHG15 | KLF2 down regulation | Pancreatic cancer | 48T 48Â N tissues AsPC-1, BxPC-3 and PANC-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Ma (129) |
DUXAP8 | KLF2 down regulation | Pancreatic cancer | 58T tissues AsPC-1, BxPC-3, and PANC-1 cell lines Athymic mice | Tumor suppressor | Diagnosis | 2018 | Lian (130) |
LINC00702 | KLF2 down regulation | Ovarian cancer | 36T 36Â N tissues ES-2, SKOV-3, A2780, and HEY cell lines | Tumor suppressor | Diagnosis | 2019 | Wang (137) |
SNHG7 | KLF2 down regulation | Ovarian cancer | 30T 30Â N tissues A2780, OCC1, H8710 and SK-OV3 cell lines Nude mice | Tumor suppressor | Diagnosis | 2020 | Bai (138) |
GHET1 | KLF2 down regulation | Prostate cancer | 30T 30Â N tissues LNCap and C4-2 cell lines | Tumor suppressor | Diagnosis | 2019 | Zhu (143) |
LINC00665 | KLF2 down regulation | Prostate cancer | 50T 50Â N tissues PC-3, DU-145, 22RV1, LNCaP cell lines Nude mice | Tumor suppressor | Diagnosis | 2021 | Xue (144) |
SNHG6 | KLF2 down regulation | Osteosarcoma | 58T 58Â N tissues KHOS, MG-63, and U2OS cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Ruan (165) |