Table 2 KLF2 functions as a tumor suppressor or oncogene by the transcriptional regulation of target genes
From: PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression
KLF2 target gene | Tumor Type | Samples | KLF2 Function | Clinical Application | Year | Study |
|---|---|---|---|---|---|---|
TGF-β/Smad down regulation | Hepatocellular carcinoma | SMMC-7721, MHCC97H, MHCC97L, and HCCLM3 cell lines | Tumor suppressor | Diagnosis | 2020 | Li (14) |
PTEN/AKT down regulation | Gastric cancer | 15T 15Â N tissues HGC-27, SNU-1, SGC-7901, NCI-N87, KATOIII, AGS, MKN-28, MKN-45, BGC-823, MGC-803 and GES-1 cell lines Nude mice | Tumor suppressor | Diagnosis and prognosis | 2017 | Wang (54) |
P21 up regulation | Colon cancer | HCT116, mutp53, SW1116, and HEK293A cell lines | Tumor suppressor | Diagnosis | 2019 | Lu (66) |
HIF-1Α/ NOTCH-1 down regulation | Colorectal cancer | SW480 HT29, SW620 and HCT116 cell lines | Tumor suppressor | Diagnosis | 2017 | Wang (74) |
WEE1 down regulation | Ovarian cancer | OV167, OV177, OV202 and OV207 cell lines | Tumor suppressor | Diagnosis | 2005 | Wang (77) |
P21/ P15 up regulation | Non-small cell lung cancer | 113T 113Â N tissues A549, SPC-A1, SK-MES-1, NCI-H1299, and NCI-H1650 cell lines | Tumor suppressor | Diagnosis and prognosis | 2015 | Yin (82) |
P15/ P21 up regulation | Non-small cell lung cancer | 47T 47Â N tissues A549, HCC827, SK-MES-1, NCI-H1299 and NCI-H1975 cell lines | Tumor suppressor | Diagnosis and prognosis | 2017 | Jiang (84) |
Glutamine transaminase down regulation | Non-small cell lung cancer | A549, NCI-H1299 cell lines | Tumor suppressor | Diagnosis | 2020 | Xiao (99) |
Hedgehog/Gli1 down regulation | Hepatocellular carcinoma | 38T 38Â N tissues L02, Chang, 7404 and Huh-7 cell lines Nude mice | Tumor suppressor | Diagnosis | 2019 | Lin (104) |
C-Myc up regulation | Hepatocellular carcinoma | 60T 60Â N tissues HuH-7 and HepG2 cell lines Nude mice | Oncogene | Diagnosis | 2016 | Zou (114) |
B-Catenin/TCF down regulation | Pancreatic cancer | 52T 52Â N tissues BXPC3 and Suit2 cell lines | Tumor suppressor | Diagnosis | 2016 | Zhang (127) |
P21 up regulation | Pancreatic cancer | HPAC and SW1990 cell lines Nude mice | Tumor suppressor | Diagnosis | 2020 | Yuedi (131) |
P16, P21, And P27 up regulation and CCND1/ Survivin down regulation | Breast cancer | 20T 20Â N tissues MCF10A, MCF-7, T47D, SK-BR-3, CAL-51 and MDA-MB-231cell lines | Tumor suppressor | Diagnosis | 2022 | Zhu (136) |
MMP2 down regulation | Prostate cancer | 30T 30Â N tissues PC-3 and 22Rv1 cell lines | Tumor suppressor | Diagnosis | 2019 | Wang (142) |
IRF4 up regulation | Multiple myeloma | 3T tissues RPMI8226, MM.1Â S and U266 cell lines | Oncogene | Diagnosis | 2016 | Ohguchi (154) |