Table 1 Fold change regulation of mitochondria-related genes detected in the EGCG-EVs vs EVs

MT-ATP8

− 6.64

3.99E-33

ATP synthase 8

MCUB

− 5.60

0.013846

Mitochondrial Calcium Uniporter Dominant Negative Subunit Beta. An integral component of the mitochondrial inner membrane

MT-ATP6

− 4.50

1.75E-11

ATP synthase 6

MT-ND2

− 4.33

4.73E-64

NADH dehydrogenase 2

MT-ND4

− 3.90

1.67E-44

NADH dehydrogenase 4

MT-CO2

− 3.81

8.09E-15

Cytochrome C oxidase II

MT-CYB

− 3.38

4.72E-12

Cytochrome b

MT-ND5

− 3.35

1.97E-34

NADH dehydrogenase 5

MT-CO3

− 3.16

4.84E-11

Cytochrome C oxidase III

MT-ND3

− 3.15

4.86E-44

NADH dehydrogenase 3

MT-ND4L

− 3.01

3.07E-38

NADH 4L dehydrogenase

MT-ND1

− 2.98

3.01E-29

NADH dehydrogenase 1

MT-CO1

− 2.41

9.83E-19

Cytochrome C oxidase I

MT-ND6

− 2.03

3.01E-10

NADH dehydrogenase 6

FIS1

− 2.03

0.0415208

Component of a mitochondrial complex that promotes mitochondrial fission

VDAC1

− 1.08

0.0247492

Voltage Dependent Anion Channel 1. A major component of the outer mitochondrial membrane