Fig. 3

A summary of FOXM1 regulation in gliomas. Activation of growth factors and tyrosine kinases can subsequently promote FoxM1 translocation to the nucleus via inducing its translocation. In the nucleus, FOXM1 can transcriptionally regulate the expression of various targets by biding to their promoter, while several transcription factors (e.g., HSF1, FGFR1, HIF-1a, and HMGA2) can transactivate FOXM1. In addition, several miRNAs that target 3’ UTR of FOXM1 mRNA are downregulated in glioma cell lines. All of these processes lead to cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemoradiotherapy