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Fig. 1 | Cancer Cell International

Fig. 1

From: Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma: implications for prognosis, immune infiltration, and therapeutic strategies

Fig. 1

The disulfidptosis-related gene SLC7A11 was deregulated in cancers and related to prognosis in ACC. A Two sets of genes associated with disulfidptosis have 15 crossover genes: SLC7A11, INF2, CD2AP, PDLIM1, ACTN4, MYH9, MYH10, IQGAP1, FLNA, FLNB, TLN1, MYL6, ACTB, DSTN, and CAPZB. B Three genes involved in disulfidptosis, SLC7A11, ACTB, and MYL6, were differentially expressed between ACC and normal adrenal tissues. SLC7A11 expression was higher in ACC tissue than in normal adrenal tissue. C Two disulfidptosis-related genes, SLC7A11 and MYL6, were associated with prognosis in ACC patients. D, E Kaplan‒Meier survival curve of overall survival in ACC patients based on the expression of SLC7A11 and MYL6. F Expression levels of SLC7A11 in urothelial tumours and corresponding normal tissues were investigated using TCGA and GTEx databases. ACC, adrenocortical cancer; BLCA, bladder urothelial carcinoma; KIRC, kidney clear cell carcinoma; KICH, kidney chromophobe; KIRP, kidney papillary cell carcinoma; PRAD prostate adenocarcinoma; PCPG pheochromocytoma & paraganglioma; TGCT testicular germ cell tumour. *P value < 0.05, **P value < 0.01, ***P value < 0.001

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Cancer Cell International

ISSN: 1475-2867

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