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Fig. 5 | Cancer Cell International

Fig. 5

From: Therapeutic effect and transcriptome-methylome characteristics of METTL3 inhibition in liver hepatocellular carcinoma

Fig. 5

Inhibition of METTL3 suppressed CDX tumor growth in nude mice. A, B Knocking-down METTL3 and inhibition on METTL3 significantly suppressed tumorigenicity in the subcutaneously implanted mouse model. C Weight of the dissected tumors in vehicle group and STM2457 treatment group. D The top 20 most significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of downregulated and upregulated genes in CDX tumors treated with STM2457 when compared with vehicle. Data were shown as replicated experiments. Term candidate gene number and Q-value are indicated

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Cancer Cell International

ISSN: 1475-2867

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