Fig. 6
Integrated analyses of transcriptome and METTL3-m6A dependent pathways. A Venn diagram illustrating the intersection of genes identified as m6A-hypomethylated by MeRIP analysis in xenograft with shMETTL3_cells compared to shControl_cells, genes identified as down-regulated by RNA-seq analysis in shMETTL3_cells compared to shControl_cells, and genes identified as down-regulated by RNA-seq analysis in STM2457-treated xenograft bodies compared to control mice. B Enriched Gene Ontology Biological Process (GO_BP) terms for the overlapping genes identified in A. C Venn diagram illustrating the intersection of genes identified as m6A-hypomethylated by MeRIP analysis in xenograft bodies with shMETTL3_cells compared to shControl_cells, genes identified as up-regulated by RNA-seq analysis in shMETTL3_cells compared to shControl_cells, and genes identified as up-regulated by RNA-seq analysis in STM2457-treated nude mice compared to control mice. D GO_BP terms for the overlapping genes identified in C.