Fig. 7
Targeting METTL3 reverses activation of MAPK cascades. A Overlay m6A peaks revealed SMAD3 and MAPK pathway-related genes as METTL3 targets. B qRT-PCR verification of the expression of EGFR, SMAD3, DUSP5, and SPRY2 genes in control Huh7 xenografts and that treated with STM2457 or with METTL3 knocking-down. C Immunoblot shows expression of METTL3, SPRY2, EGFR, ERK1/2, and phosphorylated ERK1/2 in control Huh7 xenografts or Hep3B cells and their counterparts treated with STM2457 or with METTL3 knocking-down.