Fig. 8
Working model of METTL3-mediated modulation of m6A-modified mRNAs within the MAPK cascades. mRNAs were methylated by the methyltransferase METTL3. The stability of EGFR, when modified by m6A, was observed to increase, while the degradation of SPRY2, when modified by m6A, was found to occur preferentially. The targeting of METTL3 leads to the stable translation and accumulation of SPRY2, which subsequently suppresses the MAPK cascades