Fig. 4

Functional enrichment analysis of the genes and proteins differentially expressed in the RKIP KO GIST-T1 cell line. Lollipop plots from the functional enrichment analysis done at ShinyGo 0.77 tool (http://bioinformatics.sdstate.edu/go/), showing up to 10 Top KEEG enriched pathways at mRNA (A) and protein level (B). Enriched pathways were sorted considering the -log10(FDR) values, the size of de circles is proportional to the gene numbers, and the color of the bars corresponds to the fold enrichment. (C and D): The functional protein association network was done in the STRING tool (https://string-db.org/), showing the 3 main significant interaction nodes within the network, at the mRNA and protein levels, respectively. Dot lines are showing the common pathways and signalizing the RKIP (PEBP1) position in the nodes