Fig. 6

Gene expression profiles of DEGs and enriched GO and KEGG pathways the DEGs involved. A The Venn Diagram showed the overlapping upregulated (upper figure) and downregulated (lower figure) DEGs among triplicate experiments. B Heatmap of gene expression profiles between CD8 + T cells and EV-treated-CD8 + T cells by hierarchical clustering. The gene abundance is shown with color from high (red) to low (blue). C Representative enriched GO term, including BP, CC, and MF. D Enriched KEGG pathways were performed for the DEGs. The color bar represents adjusted P value, and the numbers in the bars give the gene numbers involved in the certain signal pathway. DEGs differentially expressed genes, GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, BP biological process, CC cellular component, MF molecular function