From: Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms
Cell type | Species | Exp. | Target genes | Description of target gene | Mig. | Potential diseases | Ref |
---|---|---|---|---|---|---|---|
Bone marrow-derived endothelial progenitor cells | Rat | ↓ | c-Myb | Inhibiting migration and tube formation of endothelial cells | ↓ | Deep venous thrombosis | [110] |
Brain microvascular endothelial cells | Mouse | ↑ | Vezf1 | A zinc finger transcription factor involved in tube formation and angiogenesis | ↓ | Fetal alcohol spectrum disorders | [111] |
Human aortic smooth muscle cells and mice model | Human and Mouse | ↓ | STAT1 | A transcription factor which is mainly increases cell motility | ↑ | Atherosclerosis | [112] |
HTR-8/SVneo (a trophoblast cell line) and placenta cells | Human | ↑ | VEGF and MMP9 | VEGF and MMP9 contribute to extravillous trophoblast cell migration to induce placental vascular remodeling during pregnancy | ↓ | Preeclampsia | [113] |
Isolated monocytes from human and mouse model | Human and Mouse | ↓ | CXCR4 | The CXCR4 receptor binds its ligands and triggers cell migration | ↑ | Acute myocardial infarction | [114] |
Pulmonary artery smooth muscle cells | Human | ↓ | HIF-1a | HIF-1α has been shown to elevate cell motility through the activation of RhoA | ↑ | Pulmonary arterial hypertension | [115] |
Brain microvascular endothelial cells and rat model | Human and Rat | ↑ | VEGF | It is involved in angiogenesis during poststroke recovery | ↓ | Poststroke recovery | [116] |
CRL-7566 cells (derived from an ovarian cyst wall from a patient) | Human | ↑ | PDCD4 | A tumor suppressor protein that is involved in EMT suppression | ↑ | Endometriosis | [117] |
Bone marrow-derived mononuclear cells | Human | ↑ | CXCR4 | The receptor of stromal cell-derived factor that has an essential role in stem cell migration | ↓ | Ischemia | [118] |
Mouse model of oxygen-induced proliferative retinopathy | Mouse | ↑ | CXCR4, DLL4, and FZD4 | miR-150 targets angiogenesis-related genes and reduce endothelial cell migration and tubular formation | ↓ | Pathologic ocular neovascularization | [119] |
Leiomyoma cells | Human | ↓ | Akt | Akt is a crucial cell survival and migration regulator. | ↑ | Uterine leiomyoma | [120] |