Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

Table 2 miR-150 is known as a modulator of epithelial-mesenchymal transition in various cancer

Type of cancer	Expression	Non-coding RNA	Target gene	Description of target gene	Signaling pathway	Ref
Ovarian and esophageal squamous cell carcinoma	Decreased		ZEB1	EMT-associated transcription factor		[18, 19]
Non-small cell lung cancer	Decreased	Linc00673				[21]
Osteosarcoma	Decreased	MIAT				[22]
Oral squamous cell carcinoma	Decreased		HMGA2	This transcription factor modulates several genes involved in EMT		[24]
Non-small cell lung cancer	Increased		FOXO4	FOXO4 is known as NF-κB/Snail axis inhibitor	NF-κB	[26]
Ovarian	Increased		c-Myb	Inhibiting c-Myb leads to the induction of Slug levels, an EMT-associated transcription factor		[29]
Colorectal cancer	Increased		EP300 and CREB1	Transcription factors related to CREB signaling pathway	Wnt/β-catenin and CREB	[33]
Prostate cancer	Decreased		TRPM4	This non-specific ion channel promotes the activation of the Wnt/β-catenin signaling pathway	Wnt/β-catenin	[37]
Cervical carcinoma	Increased		SRCIN1	A tumor suppressor	SRC tyrosine kinase	[40]
Lung cancer	Increased					[42]
Breast cancer	Increased					[43]
Gastric cancer	Increased					[44]
Hepatocellular carcinoma	Decreased		GAB1	a scaffolding linker that regulates signal transmission between receptors and subsequent signaling pathways	ERK	[9]
Melanoma	Decreased	circVANGL1			TGFβ	[50]

ISSN: 1475-2867