Table 3 Direct targets of miR-150 and Its outcomes in migration of various cancer cells

Matrix metalloproteinases

Cervical

Up

PDCD4

PDCD4 is an inhibitor of MMP-9. Targeting PDCD4 elevates MMP-9 levels.

[57]

Glioblastoma

Down

MT1-MMP

MiR-150 targets MT1-MMP, a type of MMPs family

[58]

Hepatocellular

Down

MMP14

MMP14 degrades an ECM and facilitates cancer cells migration

[60]

lung

Down

MMP14

FAM83A-AS1 is a lncRNA that down-regulates miR-150 directly and increases MMP14 levels indirectly.

[61]

Breast

Down

MMP13

miR-150 is down-regulated by LINC00511 and MMP13 is upregulated

[62]

Cell adhesion molecules

Prostate and head and neck squamous cell

Down

SPOCK1

Ca2+-binding proteoglycan, SPOCK1 has a role in cell-cell and cell-matrix interaction

[63, 64]

Head and neck squamous cell

Down

ITGA3, ITGA6 and TNC

Integrins and TNC are transmembrane receptors and ECM-related glycoproteins, respectively.

[11]

Colorectal and

pancreatic

Down

MUS4

MUS4 is a transmembrane glycoprotein that is enhanced in cancers and promotes metastasis

[70, 71]

Transcription factors

Melanoma

Down

MYB

MYB encodes a migration-mediated transcription factor

[75]

Colorectal

Down

iASPP

iASPP is the inhibitor of the p53 transcription factor

[76]

Ovarian

Down

Sp1 and ZFAS1

miR-150-5p is inhibited by ZFAS1, and Sp1 is upregulated and triggers the expression of migration-related genes.

[81]

Ovarian

Down

MIAT

MIAT is lncRNA sponging miR-150

[82]

Epigenetics

Breast

Down

HMGA2

Up-regulation of HMGA2, a chromatin remodeling-related factor, triggers breast cancer cell migration.

[84]

Thyroid

Down

EZH2

Upregulation of MIAT sponges miR-150 and induces EZH2 levels, which is important for thyroid cancer cell migration.

[86]