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Fig. 5 | Cancer Cell International

Fig. 5

From: TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment

Fig. 5

Correlation between TSTA3 expression and lysosomal pathway in LUSC. A, B The expression of lysosomal acid hydrolase (A) and lysosomal membrane proteins (B) in H226 cells with TSTA3-OE and NC group by RT-qPCR. C, D The mRNA expressions of LAMP2, CD63, LAPTM4A, CD68, HGSNAT, SCRAB2 and SLC17A5 in TSTA3 overexpressing H226 (C) and H1703 (D) cells. E, F The mRNA expressions of LAMP2, CD63, LAPTM4A, CD68, HGSNAT, SCRAB2 and SLC17A5 in TSTA3 knockdown H226 (C) and H1703 (D) cells. G The protein level of LAMP2 in TSTA3-knockdown or stably overexpressed H226 cells by Western blot. H Determine whether LAMP2 and TSTA3 are correlated using the TIMER database. I Immunohistochemistry detects the expression level of LAMP2 in tumor tissues of xenograft mice. Scale bar, 250 μm and 50 μm. *** P < 0.001; ** P < 0.01; * P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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