Table 2 The association of gene expression of PFKFB family members with survival in oral cancer patients from TCGA database
Variable | ROC | No. (%) | CHR (95% CI) | p value* | AHR (95% CI) | p value†|
|---|---|---|---|---|---|---|
Overall survival | ||||||
 PFKFB1 | Low | 265 (99.6) | 1 |  | 1 |  |
High | 1 (0.4) | 5.33 (0.73–38.66) | 0.098 | 4.25 (0.59–30.89) | 0.153 | |
 PFKFB2 | Low | 210 (78.9) | 1 |  | 1 |  |
High | 56 (21.1) | 1.20 (0.77–1.86) | 0.421 | 1.28 (0.82–2.00) | 0.274 | |
 PFKFB3 | Low | 25 (9.4) | 1 |  | 1 |  |
High | 241 (90.6) | 2.77 (1.02–7.51) | 0.046 | 1.93 (0.70–5.31) | 0.201 | |
 PFKFB4 | Low | 164 (61.7) | 1 |  | 1 |  |
High | 102 (38.3) | 1.21 (0.83–1.75) | 0.323 | 1.13 (0.78–1.64) | 0.519 | |
Progression-free interval survival | ||||||
 PFKFB1 | Low | 71 (26.7) | 1 |  | 1 |  |
High | 195 (73.3) | 1.18 (0.75–1.84) | 0.480 | 1.22 (0.78–1.92) | 0.381 | |
 PFKFB2 | Low | 243 (91.4) | 1 |  | 1 |  |
High | 23 (8.6) | 1.15 (0.60–2.20) | 0.680 | 1.32 (0.67–2.59) | 0.418 | |
 PFKFB3 | Low | 240 (90.2) | 1 |  | 1 |  |
High | 26 (9.8) | 2.14 (1.25–3.65) | 0.005 | 1.85 (1.08–3.19) | 0.025 | |
 PFKFB4 | Low | 203 (76.3) | 1 |  | 1 |  |
High | 63 (23.7) | 1.35 (0.88–2.05) | 0.166 | 1.38 (0.91–2.11) | 0.133 | |
Disease-free interval survival | ||||||
 PFKFB1 | Low | 241 (95.3) | 1 |  | 1 |  |
High | 12 (4.7) | 2.20 (0.50–9.67) | 0.295 | 2.24 (0.51–9.84) | 0.286 | |
 PFKFB2 | Low | 201 (79.4) | 1 |  | 1 |  |
High | 52 (20.6) | 21.62 (0.00–673172.18) | 0.560 | 535,827.78 (0.00-) | 0.987 | |
 PFKFB3 | Low | 225 (88.9) | 1 |  | 1 |  |
High | 28 (11.1) | 1.82 (0.64–5.21) | 0.264 | 1.92 (0.66–5.56) | 0.229 | |
 PFKFB4 | Low | 194 (76.7) | 1 |  | 1 |  |
High | 59 (23.3) | 1.61 (0.59–4.36) | 0.350 | 1.51 (0.55–4.15) | 0.419 | |
Disease-specific survival | ||||||
 PFKFB1 | Low | 16 (20.8) | 1 |  | 1 |  |
High | 61 (79.2) | 1.58 (0.64–3.93) | 0.325 | 1.38 (0.55–3.44) | 0.490 | |
 PFKFB2 | Low | 3 (3.9) | 1 |  | 1 |  |
High | 74 (96.1) | 1.45 (0.84–2.50) | 0.188 | 1.51 (0.87–2.63) | 0.146 | |
 PFKFB3 | Low | 63 (81.8) | 1 |  | 1 |  |
High | 14 (18.2) | 2.74 (1.54–4.87) | 0.001 | 2.43 (1.36–4.37) | 0.003 | |
 PFKFB4 | Low | 35 (45.5) | 1 |  | 1 |  |
High | 42 (54.5) | 1.35 (0.80–2.28) | 0.259 | 1.43 (0.85–2.41) | 0.184 | |