Fig. 1
From: Exosomal circRNA RHOT1 promotes breast cancer progression by targeting miR-204-5p/ PRMT5 axis
Serum exosomal circRHOT1 is relatively highly expressed in breast cancer and has a good diagnostic value
A, Heatmap analysis of the circRNA expression profile in breast cancer (patients from the GSE101124 dataset). B, Volcano plot showing the circRNA expression profile in breast cancer (patients from the GSE101124 dataset). C, Representative images of exosomes isolated from breast cancer patients under the transmission electron microscope. (The arrows indicate the exosomes with a double-layer membrane). D, The expressions of exosome markers. The control group represented the residual cells after exosome isolation; while the EX-Breast Cancer group represented exosomes isolated from the serum of breast cancer. E, Expression of exosomal circRHOT1 in the serum of healthy control and breast cancer patients. The relative expression of circ-RHOT1 was normalized to GAPDH. F, Expression of circRHOT1 in tumor tissues of healthy control and breast cancer patients. G, The diagnostic value of exosomal circRHOT1 in breast cancer (AUC = 0.8300, P＜0.01). Compared with healthy control, ** p < 0.01