Fig. 1
From: CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling
Apoptotic phenotype correlates with TCGA subtype and prognosis in gastric cancer. (A) Heatmap showing the expression of marker genes in several functional gene sets in The Cancer Genome Atlas (TCGA) gastric cancer cohort. (B) Relative protein levels in The Cancer Proteome Atlas (TCPA) cohort. *p < 0.05, ***p < 0.001, and ****p < 0.0001. (C) The violin plot displays the scores of epithelial–mesenchymal transition (EMT) and cytotoxic T-cell signatures calculated by single sample gene set enrichment analysis (ssGSEA). The values are normalized to the z score. Ns indicates no significance, **p < 0.01, and ****p < 0.0001. (D and E) Correlation of apoptotic phenotype (APTcluster) with clinicopathological characteristics in the TCGA or Asian Cancer Research Group (ACRG) cohorts displayed in a Sankey diagram (D) and percentage histogram (E). (F) Kaplan–Meier survival analysis for patients with different apoptotic phenotypes in the ACRG and GSE26942 cohorts