Fig. 3
From: CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling
CDK5 is a potential proapoptotic gene in gastric cancer. (A and B) Venn diagram shows differentially expressed genes (DEGs) among the apoptotic phenotypes from the TCGA, ACRG, and GSE26942 cohorts. Ten and 12 robust genes with differential expression were further identified by merging the three cohorts of anti- (A) or proapoptotic DEGs (B), respectively. (C) The histogram indicates that cyclin-dependent kinase 5 (CDK5) expression gradually increased in the proapoptotic (Cluster A), intermediate (Cluster B), and antiapoptotic phenotypes (Cluster C). (D) Heatmap showing copy number variations of CDK5 in each apoptotic phenotype