Table 1 Expression of BBOX1-AS1 and its associations with clinical features, prognosis, and diagnosis in human tumor samples

Pituitary adenoma

Upregulated

~ 6.5-fold

38 pairs of adenoma and adjacent normal tissues (qRT-PCR)

–

–

–

[34]

Oral squamous cell carcinoma

Upregulated

~ 4-fold

50 pairs of adenoma and adjacent normal tissues (qRT-PCR)

–

–

–

[35]

Nasopharyngeal carcinoma

Upregulated

~ 2.5-fold

45 pairs of adenoma and adjacent normal tissues (qRT-PCR)

–

–

–

[37]

Nasopharyngeal carcinoma

Upregulated

~ 6-fold

45 paired of adenoma and adjacent normal tissues (qRT-PCR)

–

–

–

[36]

Non-small cell lung cancer

Upregulated

~ 1.5-fold

135 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Lymph node metastasis, TNM stage

OS

–

[40]

Non-small cell lung cancer

Upregulated

~ 2-fold

76 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Tumor size, lymph node metastasis, TNM stage

OS

–

[39]

–

526 cancer and 59 normal samples in LUAD, and 501 cancer and 49 normal samples in LUSC (starBase v3.0 database)

–

486 cancer and 338 normal samples in LUSC (GEPIA database)

–

GEO datasets (GSE18842 and GSE19188)

Lung squamous cell carcinoma

Upregulated

–

3 pairs of LUSC tissues and normal lung tissues (qRT-PCR)

Ethnicity

–

AUC of 0.983 (95% CI 0.973–0.993, P < 0.0001)

[38]

–

502 cancer and 49 normal samples in LUSC (TCGA dataset)

–

GEO datasets (GSE19188, GSE30219, GSE103512, E‑MTAB‑5231)

Esophageal carcinoma

Upregulated

~ 12-fold

45 pairs of adenoma and adjacent normal tissues (qRT-PCR)

–

–

–

[45]

Esophageal squamous cell carcinoma

Upregulated

~ 2-fold

78 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Tumor size, lymph node metastasis, TNM stage

OS

[44]

–

182 adenoma and 286 normal tissues (GEPIA database)

Esophageal squamous cell carcinoma

Upregulated

~ 2.75-fold

45 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Tumor size

OS

AUC of 0.7668 (95% CI 0.6399 to 0.8937, P < 0.001)

[43]

–

182 adenoma and 13 normal tissues (GEPIA database)

Esophageal squamous cell carcinoma

Upregulated

–

182 adenoma and 286 normal tissues (GEPIA database)

–

–

–

[42]

–

162 cancer and 11 normal samples (starBase v3.0 database)

Esophageal carcinoma

Upregulated

~ 3.75-fold

45 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Lymph node metastasis, TNM stage

OS

–

[41]

Gastric cancer

Upregulated

~ 3-fold

40 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Lymph node metastasis

–

–

[48]

–

408 tumor samples and 211 normal samples (GEPIA database)

Hepatocellular carcinoma

Upregulated

~ 2-fold

83 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Vascular invasion, TNM stage

OS

–

[46]

Hepatocellular carcinoma

Upregulated

~ 2-fold

374 tumor samples and 50 normal samples (GENCODE database)

Vascular invasion, tumor grade, tumor stage

OS, DFS

[47]

Ovarian cancer

Upregulated

–

426 tumor samples and 88 normal samples (TCGA database)

–

–

–

[51]

Cervical cancer

Upregulated

~ 2-fold

100 pairs of adenoma and adjacent normal tissues (qRT-PCR)

Tumor size, differentiation, distant metastasis, FIGO stage

OS

–

[53]

–

306 tumor samples and 13 normal samples (GEPIA database)

Cervical cancer

Upregulated

–

306 tumor samples and 13 normal samples (GEPIA database)

–

–

–

[52]