Table 3 The functions and regulatory mechanisms of BBOX1-AS1 in different human cancers
Tumor type | Expression | Experiments | Functions | Regulatory mechanism | Signaling pathway | Ref. | |
|---|---|---|---|---|---|---|---|
Tumor vs. normal cell lines | Subcellular locations | ||||||
Pituitary adenoma | Upregulated | Mainly in the cytoplasm | In vitro/in vivo | Cell proliferation, invasion, apoptosis inhibition; tumor growth | BBOX1-AS1/miR-361-3p/E2F1 | – | [34] |
Oral squamous cell carcinoma | Upregulated | Mainly in the cytoplasm | In vitro | Cell proliferation, migration, apoptosis inhibition | BBOX1-AS1/miR-3940-3p/LAMC2 | – | [35] |
Nasopharyngeal carcinoma | Upregulated | Mainly in the cytoplasm | In vitro/in vivo | Cell viability, migration, apoptosis inhibition; tumor growth | BBOX1-AS1/miR-204-5p/MUC4 | – | [36] |
Nasopharyngeal carcinoma | Upregulated | – | In vitro | Cell proliferation, migration, invasion | BBOX1-AS1/miR-3940-3p/KPNA2 | – | [37] |
Non-small cell lung cancer | Upregulated | – | In vitro | Cell proliferation, migration, invasion | BBOX1-AS1/miR-361-3p | – | [40] |
Non-small cell lung cancer | Upregulated | Predominantly in the cytoplasm | In vitro/in vivo | Cell proliferation, migration, invasion, EMT; tumor growth | BBOX1-AS1/miR-27a-5p/MELK | MELK/FAK signaling | [39] |
Lung squamous cell carcinoma | Upregulated | Mainly in the cytoplasm | In vitro | Cell proliferation, migration, cell cycle arrest | – | – | [38] |
Esophageal carcinoma | Upregulated | Mainly in the cytoplasm | In vitro/in vivo | Cell proliferation, apoptosis inhibition; tumor growth | BBOX1-AS1/miR-361-3p/COL5A1 | – | [45] |
Esophageal squamous cell carcinoma | Upregulated | – | In vitro/in vivo | Cell proliferation, invasion, migration, apoptosis inhibition, ferroptosis inhibition; tumor growth and proliferation | BBOX1-AS1/miR-513a-3p/SLC7A11 | – | [44] |
Esophageal squamous cell carcinoma | Mostly in the nucleus | In vitro | Cell proliferation, migration, invasion, apoptosis inhibition | HOXB7, β-catenin | Wnt/β-catenin pathway | [43] | |
Esophageal squamous cell carcinoma | Upregulated | Mainly distributed in the cytoplasm | In vitro | Cell proliferation, stemness | BBOX1-AS1/miR-506-5p/EIF5A/PTCH1 | Hedgehog signaling pathway | [42] |
Esophageal carcinoma | Upregulated | Principally in the cytoplasm | In vitro/in vivo | Cell proliferation, viability, migration, apoptosis; tumor growth and proliferation | BBOX1-AS1/miR-361-3p/COL1A1 | – | [41] |
Gastric cancer | Upregulated | Mainly in the cytoplasm | In vitro/in vivo | Cell proliferation, invasion, apoptosis inhibition; tumor growth | BBOX1-AS1/miR-361-3p/MUC13 | – | [48] |
Colorectal cancer | Upregulated | Mainly in the cytoplasm | In vitro | Cell proliferation, migration, invasion, apoptosis inhibition | BBOX1-AS1/miR-361-3p/SH2B1 | – | [50] |
Hepatocellular carcinoma | Upregulated | Predominantly in the cytoplasm | In vitro/in vivo | Cell proliferation, invasion, apoptosis inhibition, EMT, autophagy, cell viability, sorafenib resistance; tumor growth, proliferation, EMT, tumor metastasis | BBOX1-AS1/miR-361-3p/PHF8 | – | [46] |
Hepatocellular carcinoma | – | – | In vitro/in vivo | Cell proliferation, migration, invasion, cell cycle arrest; tumor growth | – | – | [47] |
Ovarian cancer | Upregulated | In vitro | Cell proliferation, apoptosis inhibition | BBOX1-AS1/miR-361-3p/PODXL | – | [51] | |
Cervical cancer | Upregulated | Mainly in the cytoplasm | In vitro/in vivo | Cell proliferation, apoptosis inhibition, migration, invasion; tumor growth, proliferation, EMT | BBOX1-AS1/miR-361-3p/HOXC6/HuR | – | [53] |
Cervical cancer | – | – | – | – | BBOX1-AS1-hsa-miR-125b-5p/hsa-miR-125a-5p-CDKN2A | – | [52] |