The impact of gut bacteria producing long chain homologs of vitamin K2 on colorectal carcinogenesis

Table 2 Vitamin VK₂-MK4 penetration inside the Caco-2 tissue. Measured vitamin VK₂-MK4 levels in mg/L

Sample	Without VK₂-MK4 addition			4.4 mg/L VK₂-MK4 addition			44 mg/L VK₂-MK4 addition
Sample	24 h	48 h	72 h	24 h	48 h	72 h	24 h	48 h	72 h
Post-culture supernatant (DMEM)	<LOD	<LOD	<LOD	2.3	1.3	2.8	13	8.6	9.0
PBS form third rinsing	<LOD	<LOD	<LOD	0.2	0.1	0.2	0.6	0.6	0.7
Crushed Caco-2 cells	<LOD	<LOD	<LOD	0.2	0.1	1.7	12	22	11

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