Metal nanoparticles as a potential technique for the diagnosis and treatment of gastrointestinal cancer: a comprehensive review

Table 4 The studies employing MNPs for hepatocellular carcinoma treatment

Type of nanoparticles	Size	Major outcome	Targeting approach (Passive or Active)	Model ( In vivo, In vitro)	Type of cell line	Ref
gold	1–100 nm	delayed tumor growth	Passive	In vitro	Huh7	[180]
gold	35 nm	enhanced the tumor suppressors	Passive	In vitro	HepG2	[181]
gold	1–100 nm		Passive	In vitro	HepG2	[182]
gold	19 ± 0.37 nm	decreased tumor growth	Passive	In vitro	HepG2	[183]
gold	13 nm	inhibit proliferation of HCC cell	Passive	In vitro	HepG2 and Huh7	[173]
gold	13 nm	high tumor uptake	Passive	both	Hep3B and HepG2	[184]
gold	10 nm	suppress hepatocellular carcinoma growth	Passive	both	HepG2	[185]
gold	83.7 ~ 103.6 nm	Anti-Metastatic Effect	Passive	In vitro	HepG2 and SK-Hep-1	[186]
gold	40 and 80 nm	Inhibited Cytochrome P450 3A4 Activity and Molecular Mechanisms Underlying Its Cellular Toxicity	Passive	In vitro	C3A	[179]
silver	30.71 nm	Induced ROS and cell apoptosis in HepG2 cell line	Passive	In vitro	HepG2	[187]
silver		focal necrosis and inflammatory cell infiltration	Passive	In vivo	mice	[188]

ISSN: 1475-2867