Fig. 1
From: VISTA and its ligands: the next generation of promising therapeutic targets in immunotherapy
VISTA gene regulation in inflammation and cancer. Under inflammatory conditions, transcription factors, including NF-κB, Fos, and JunD attach to the VISTA promoter and suppress its transcription and expression. In tumor cells, increased p53 and HIF-1α bind to the promoter of VISTA and induce its expression. Additionally, BRAF neutralizes the FOXD3 inhibitory effect on VISTA expression by blocking the binding of FOXD3 to the VISTA promoter. Moreover, miR-125 has the ability to suppress VISTA translation. VISTA (V-domain immunoglobulin suppressor of T cell activation), NF-κB (nuclear factor kappa B), HIF-1α (hypoxia-inducible factor 1-alpha), Forkhead box D3 (FOXD3), miR-125 (microRNA-125). Created with BioRender.com