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Fig. 3 | Cancer Cell International

Fig. 3

From: Tumor-derived exosomal linc00881 induces lung fibroblast activation and promotes osteosarcoma lung migration

Fig. 3

Linc00881 sponge miR-29c-3p in lung fibroblasts. A. Distribution of linc00881 in HFL-1 cells assessed by the FISH assay. B. Duplex structure of miR-29c-3p and linc00881. C. Relative expression of miR-29c-3p in HFL-1 cells simulated by two OS exosomes. D. qRT-PCR detection of relative expression of linc00881 using the control or miR-29c-3p probe to perform the pull-down assay. E. qRT-PCR detection of the expression of linc00881 in HFL-1 cells transfected with linc00881 siRNA or vector. F. qRT-PCR detection of the expression of miR-29c-3p in HFL-1 cells transfected as described in E. G–K. Transwell assay of MG63 or HOS cells migrated to the HFL-1 cells transfected with: a. control mimic + control vector; b. miR-29c-3p mimic + control vector; c. control mimic + linc00881 vector; d. miR-29c-3p mimic + linc00881 vector, representative images and quantitative analysis of MG63 and HOS cells are shown in H&I and J&K, respectively. (*p < 0.05; **p < 0.01; *** p < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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