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Table 1 Clinical data of pediatric patients with MB-NHL (n = 89)

From: Impact of ARID1A and TP53 mutations in pediatric refractory or relapsed mature B-Cell lymphoma treated with CAR-T cell therapy

 

Level

Overall

n = 89

Age (mean (SD))

 

8.94 (4.39)

Gender (%)

Female

16 (18.0)

 

Male

73 (82.0)

Disease subtype (%)

BL

63 (70.8)

 

HGBL

11 (12.4)

 

DLBCL

10 (11.2)

 

Others

5 (5.6)

Stage (%)

II

2 (2.2)

 

III

43 (48.3)

 

IV

42 (47.2)

 

Unknown

2 (2.2)

CNS (%)

CNS1

52 (58.4)

 

CNS2

15 (16.9)

 

CNS3

20 (22.5)

 

Unknown

2 (2.2)

Group (%)

r/r

48 (53.9)

 

initial remission (≥ 6mounths)

28 (31.5)

 

initial remission (<6mounths)

13 (14.6)

CAR-T or not

No

49 (55.1)

 

Yes

40 (44.9)

CAR-T Response (n = 40)

NR

15 (37.5)

 

R

25 (62.5)

  1. BL, Burkitt Lymphoma; HGBL, High-grade B cell Lymphoma; DLBCL, Diffuse Large B Cell Lymphoma; CNS,Central Nervous System; NR, no response; R, response