Fig. 4

Gene set enrichment and exomiRNAs target-gene analysis of deregulated exo-miRNAs between PC-3 and LNCaP cell lines. a ExomiRNAs differentially expressed between PC-3 and LNCaP cell lines. The Venn diagram shows the number exomiRNAs under-expressed (green circle) and overexpressed (orange circle) in PC-3 regarding LNCaP. The yellow area represents exomiRNAs that are equally expressed between both cell lines. b Reactome pathway enrichment analysis list of significant pathways affected by deregulated exomiRNAs in PC-3 cells vs LNCaP cell lines and putative implicated target genes. c STRING analysis of protein–protein interaction network of exomiRNAs target genes CDK6, TNRC6B, AGO1, AGO3 and TNRC6A. Coloured circle predicted functional protein partners. Different colours lines represent different evidence of connection between proteins (Black—Co-expression, pink—experimental evidence, turquoise—database evidence)