Table 4 Tumor-suppressor and oncogenes miRNAs in NSCLC
miRNAs | miRNAs action | Effect on the expression of their target genes. | Function** | Target genes |
|---|---|---|---|---|
Let-7 | Tumor suppresser | Downregulated | A/B/C/D/E | K-RAS, MYC, HMGA2, |
miR-15a | Tumor suppresser | Downregulated | A/B | CDK6, CDC25, CyclinD1/2 |
miR-16/1 | Tumor suppresser | Downregulated | A/B | CDK6, CDC25, CyclinD1/2 |
miR-21 | Oncogenes | Downregulated | A/B/C/D/E | PTEN, BTG2, PDCD4, FASLG, RHOB |
miR-29 | Tumor suppresser | Downregulated | A/B/C | P85α, DNMTs, MCL1, P53 |
miR-31 | Oncogenes | Downregulated | A/B | LATS2, PPP2R2A, PP2A |
miR-34 family | Tumor suppresser | Downregulated | A/B/D/E | E2F1, AXL, SNAIL1 |
miR-17-92 cluster | Oncogenes | Upregulated | C/D/E/I | PTEN, HIF-1α |
miR-101 | Tumor suppresser | Downregulated | C | MLC1, EZH2 |
miR-126 | Tumor suppresser | Downregulated | A/B/I | EGFL7, VEGF-A |
miR-192 | Tumor suppresser | Downregulated | A/B | RB1 |
miR-200 family | Tumor suppresser | Upregulated | A/B/D/E/F/I | ZEB, E-cadherin, KDR, Foxf2, NFkB, ETAR, SMAD3 |
miR-212 | Tumor suppresser | Downregulated | A/B | PED, PTCH1 |
miR-218 | Tumor suppresser | Downregulated | D/E | PXN |
miR-221 | Oncogenes | Upregulated | C/D/E | PTEN, BIM, PUMA, TIMP-2 |
miR-222 | Oncogenes | Upregulated | C/D/E | PTEN, BIM, PUMA, TIMP-2 |
miR-301 | Oncogenes | Upregulated | A/B | SKA2, ERK |
miR-449 family | Tumor suppresser | Downregulated | A/B | E2F1, p53, HDACs |
miR-451 | Tumor suppresser | Downregulated | C | RAB14, Bax, Bad |
miR-494 | Oncogenes | Downregulated | C/D/E | PTEN |
miR-545 | Tumor suppresser | Downregulated | A/B | cyclin D1, CDK4 |