Table 5 Summary of studies using miRNAs mimics and anti-miRNAs in drug delivery systems for lung cancer therapy
Delivery Vehicle | Targeted miRNA | Antagonist / Mimics | Type of lung cancer | Effect | Ref |
|---|---|---|---|---|---|
Sense and antisense 2’-O-methyl oligonucleotides | miR-125-3p/5p | Mimics | NSCLC | Inhabited migration and invasion of NSCLC | [221] |
Lentiviral vector | Let-7 | Mimics | NSCLC | This tumor suppressor miRNA inhibits the growth of cultured lung cancer cells | |
LPH-PEG-GC4 | miR-34a | Mimics | SCLC/ NSCLC | Cause of programmed cell death and inhibited XXXurviving expression and downregulated MAPK pathway in B16F10 cells. | |
pMSCV-Pur vector or directly | miR-1254 | Antagonist | NSCLC | miR-1254 inhibition caused suppresses lung cancer cell proliferation. | [225] |
Cationic DOTMA lipoplexes | miR-29b | Mimics | NSCLC | Decreased expression of the main target oncogenes and suppression of cancer development. | [226] |
Lenti-miR vector or directly | miR-224 | Antagonist | NSCLC | Upregulated miR-224 expression promotes cell migration, invasion, and proliferation | [227] |
Sense/antisense | has-miR-125a-3p | Antagonist | NSCLC | Overexpression of this miRNA effectively suppresses cell development and invasion via modulating the mouse double minute 2 homolog/ p53 signaling pathway. | [228] |
NLE | miR-34a/ let-7 | Mimics | NSCLC | Suppression of tumor cell proliferation and generation of apoptosis. |