Table 1 Study population characteristics according to presence of ≥ 10 infiltrating ARG1-positive cells per 1 mm tissue core.
From: Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours
Study population | Infiltration of ≥ 10 ARG1-positive cells | |||
|---|---|---|---|---|
No | Yes | p-value (χ2) | ||
N (%) | 487 | 454 (93) | 33 (7) | |
Mean age at diagnosis, years (SD) | 75.8 (8.5) | 75.9 (8.5) | 74.6 (9.1) | |
Mean follow-up after diagnosis, years (SD) | 9.1 (7.0) | 9.2 (7.0) | 8.3 (8.1) | |
Deaths from BC (%) | 166 (34) | 152 (33) | 14 (42) | |
Deaths from other causes (%) | 274 (56) | 260 (57) | 14 (42) | |
Grade (%) | ||||
I | 54 (11) | 52 (11) | 2 (6) | 0.005 |
II | 277 (57) | 265 (59) | 12 (36) | |
III | 155 (32) | 136 (30) | 19 (58) | |
Lymph node metastasis (%) | ||||
Yes | 167 (34) | 154 (34) | 13 (39) | 0.2 |
No | 218 (45) | 208 (46) | 10 (30) | |
Unknown histology | 102 (21) | 92 (20) | 10 (30) | |
Molecular type (%) | ||||
Luminal A | 259 (53) | 247 (55) | 12 (36) | < 0.001 |
Luminal B (HER2−) | 115 (24) | 11 (24) | 5 (15) | |
Luminal B (HER2+) | 36 (7) | 34 (8) | 2 (6) | |
HER2 type | 27 (6) | 21 (5) | 6 (18) | |
5NP | 12 (2) | 11 (2) | 1 (3) | |
BP | 36 (7) | 29 (6) | 7 (21) | |
Histologic subtype (%) | ||||
Ductal (NOS) | 341 (70) | 321 (71) | 20 (61) | 0.03 |
Lobular | 63 (13) | 61 (13) | 2 (6) | |
Other | 83 (17) | 72 (16) | 11 (33) | |
ER status (%) | ||||
< 1 | 70 (14) | 58 (13) | 12 (36) | 0.004 |
≥ 1, < 10 | 17 (3) | 15 (3) | 2 (6) | |
≥ 10, < 50 | 22 (5) | 20 (4) | 2 (6) | |
≥ 50, < 90 | 63 (13) | 58 (13) | 5 (15) | |
≥ 90 | 313 (64) | 301 (66) | 12 (36) | |
Unknown | 2 (0) | 2 (0) | 0 (0) | |
Ki67 high/low (%) | ||||
Ki67 < 15% | 293 (60) | 280 (62) | 13 (39) | 0.04 |
Ki67 ≥ 15% | 192 (39) | 172 (38) | 20 (61) | |
Mitoses/10 HPF, median (IQR p25, p75) | 5 (1, 12) | 5 (1, 1) | 12 (4, 20) | |
Mitoses/10 HPF, quartiles (%) | ||||
≤ 1 cm | 128 (26) | 123 (27) | 5 (15) | < 0.001 |
> 1, ≤ 5 | 131 (27) | 126 (28) | 5 (15) | |
> 5, ≤ 12 | 117 (24) | 107 (24) | 10 (30) | |
> 12 | 111 (23) | 98 (22) | 13 (39) | |