Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients

Table 1 Associations between peripheral blood parameters and clinical characteristics of advanced gastric cancer patients

Variable	Cases, n	PD-1⁺CD8⁺T (%)			PD-1⁺CD8⁺Tm (%)			PD-1⁺CD8⁺T/PD-1⁺CD4⁺T ratio
Variable	Cases, n	≥ 21.0, n	< 21.0, n	P-value	≥ 64.3, n	< 64.3, n	P-value	≥ 0.669, n	< 0.669, n	P-value
Total patients	187	90	97		81	106		79	108
Age, years				0.355			0.177			0.266
≥ 60	112	57	55		53	59		51	61
< 60	75	33	42		28	47		28	47
Sex				0.916			0.896			0.953
Male	144	69	75		62	82		61	83
Female	43	21	22		19	24		18	25
Drinking history				0.332			0.654			0.967
Yes	137	63	74		58	79		58	79
No	50	27	23		23	27		21	29
ECOG PS				0.093			0.068			0.058
0–1	113	60	53		55	58		54	59
2	74	30	44		26	48		25	49
Stage				0.495			0.376			0.017
III	137	68	69		62	75		65	72
IV	50	22	28		19	31		14	36
Differentiation				0.099			0.475			0.046
Well or moderate	124	65	59		56	68		46	78
Poor	63	25	38		25	38		33	30
Response				< 0.001			< 0.001			< 0.001
R	122	90	32		80	42		70	52
NonR	65	0	65		1	64		9	56
PD-L1 CPS				< 0.001			< 0.001			< 0.001
≥ 5	104	81	23		78	26		65	39
< 5	83	9	74		3	80		14	69

PD-1⁺CD8⁺T PD-1⁺CD8⁺ T cells, PD-1⁺CD8⁺Tm memory PD-1⁺CD8⁺ T cells, PD-1⁺CD4⁺T PD-1⁺CD4⁺ T cells, CPS combined positive score, ECOG PS Eastern Cooperative Oncology Group Performance Status

ISSN: 1475-2867