Table 3 Distribution of the RIPK1 tag SNPs among cases and controls and their associations with EOC risk
Model | Genotype | rs6907943 | Genotype | rs9392453 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
EOC n (%) | Controls n (%) | OR (95% CI) | P value | EOC n (%) | Controls n (%) | OR (95% CI) | P value | |||
Codominant | AA | 168 (52.7%) | 186 (49.5%) | 1 | 0.7 | TT | 179 (56.1%) | 249 (66.2%) | 1 | 0.01 |
AC | 123 (38.6%) | 155 (41.2%) | 0.88 (0.64-1.20) | CT | 117 (36.7%) | 113 (30.1%) | 1.45 (1.04-2) | |||
CC | 28 (8.8%) | 35 (9.3%) | 0.88 (0.52-1.52) | CC | 23 (7.2%) | 14 (3.7%) | 2.27 (1.15-4.55) | |||
Dominant | AA | 168 (52.7%) | 186 (49.5%) | 1 | 0.4 | TT | 179 (56.1%) | 249 (66.2%) | 1 | 0.006 |
AC/CC | 151 (47.3%) | 190 (50.5%) | 0.88 (0.65-1.19) | CT/CC | 140 (43.9%) | 127 (33.8%) | 1.54 (1.12-2.08) | |||
Recessive | AA/AC | 291 (91.2%) | 341 (90.7%) | 1 | 0.8 | TT/CT | 296 (92.8%) | 362 (96.3%) | 1 | 0.042 |
CC | 28 (9.1%) | 35 (9.3%) | 0.93 (0.56-1.59) | CC | 23 (7.2%) | 14 (3.7%) | 2.00 (1.02-4) | |||
Overdominant | AA/CC | 196 (61.4%) | 221 (58.8%) | 1 | 0.48 | TT/CC | 202 (63.3%) | 263 (70%) | 1 | 0.07 |
AC | 123 (38.6%) | 155 (41.2%) | 0.89 (0.66-1.22) | CT | 117 (36.7%) | 113 (30%) | 1.35 (0.98-1.86) | |||
| Â | Allele | Â | Â | Â | Â | Allele | Â | Â | Â | Â |
| Â | A | 459 (71.5%) | 527 (70.1%) | 1 | 0.45 | T | 475 (74.5%) | 611 (81.2%) | 1 | 0.002 |
C | 179 (28.1%) | 225 (29.9%) | 0.91 (0.72-1.15) | C | 163 (25.5%) | 141 (18.8%) | 1.49 (1.15-1.92) | |||