Table 5 Association between the RIPK1 tag SNPs and EOC patient’s characteristics
Characteristics | rs6907943 | rs9392453 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | OR (95% CI)a | Genotype | OR (95% CI)a | |||||||||
AA | AC | CC | Dominant (AA vs. AC/CC) | Recessive (AA/AC vs. CC) | Overdominant (AA/CC vs. AC) | TT | CT | CC | Dominant (TT vs. CT/CC) | Recessive (CT/TT vs. CC) | Overdominant (CT vs. CC/TT) | |
Age | ||||||||||||
 ≤50 | 82 (49.1%) | 65 (38.9%) | 20 (12%) | 1.35 (0.85-2.13) | 2.5 (1.03-5.88) | 1.02 (0.64-1.64) | 85 (50.9%) | 67 (40.1%) | 15 (9%) | 1.64 (1.04-2.63) | 1.89 (0.76-4.76) | 1.43 (0.88-2.27) |
 >50 | 86 (56.6%) | 58 (38.2%) | 8 (5.3%) |  |  |  | 94 (61.8%) | 50 (32.9%) | 8 (5.3%) |  |  |  |
FIGO stage | ||||||||||||
 I-II | 52 (53.6%) | 36 (37.1%) | 9 (9.3%) | 0.64 (0.35-1.15) | 0.88 (0.31-2.46) | 0.65 (0.35-1.2) | 57 (58.8%) | 32 (33%) | 8 (8.2%) | 0.70 (0.39-1.26) | 1.37 (0.47-4.00) | 0.62 (0.33-1.15) |
 III-IV | 116 (52.2%) | 87 (39.2%) | 19 (8.6%) |  |  |  | 122 (55%) | 85 (38.3%) | 15 (6.8%) |  |  |  |
Histological type | ||||||||||||
 Serous | 117 (56%) | 74 (35.4%) | 18 (8.6%) | 1.55 (0.84-2.85) | 0.90 (0.31-2.63) | 1.63 (0.88-3.04) | 117 (56%) | 77 (36.8%) | 15 (7.2%) | 0.98 (0.53-1.82) | 1.21 (0.39-3.79) | 0.92 (0.49-1.75) |
 Non-serous | 51 (46.4%) | 49 (44.5%) | 10 (9.1%) |  |  |  | 62 (56.4%) | 40 (36.4%) | 8 (7.3%) |  |  |  |
Tumor grade b | ||||||||||||
 G1-G2 | 32 (51.6%) | 24 (38.7%) | 6 (9.7%) | 0.97 (0.5-1.89) | 1.01 (0.32-3.17) | 0.97 (0.79-1.92) | 36 (58.1%) | 23 (37.1%) | 3 (4.8%) | 1.06 (0.54-2.09) | 2.72 (0.64-11.55) | 0.81 (0.41-1.62) |
 G3 | 124 (54.6%) | 84 (37%) | 19 (8.4%) |  |  |  | 128 (56.4%) | 81 (35.7%) | 18 (7.9%) |  |  |  |