RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer

Table 6 Association between the RIPK1 tag SNPs and overall survival of EOC patients

Characteristics		Overall survival
		Multivariate survival analysis ^a			Univariate survival analysis
		HR	95% CI	P value	HR	95% CI	P value
Model	Genotype
rs6907943
Dominant	AA	1	0.25-1.2	0.13	1	0.25-1.06	0.07
Dominant	AC/CC	0.54	0.25-1.2	0.13	0.52	0.25-1.06	0.07
Recessive	AA/AC	1	0.44-5.05	0.53	1	0.46-3.69	0.63
Recessive	CC	1.48	0.44-5.05	0.53	1.3	0.46-3.69	0.63
Overdominant	AA/CC	1	0.17-1.05	0.06	1	0.18-0.94	0.035
Overdominant	AC	0.43	0.17-1.05	0.06	0.41	0.18-0.94	0.035
rs9392453
Dominant	TT	1	0.43-1.91	0.8	1	0.35-1.44	0.35
Dominant	CT/CC	0.91	0.43-1.91	0.8	0.71	0.35-1.44	0.35
Recessive	TT/CT	1	0.04-2.01	0.2	1	0.03-1.65	0.14
Recessive	CC	0.27	0.04-2.01	0.2	0.23	0.03-1.65	0.14
Overdominant	TT/CC	1	0.61-2.76	0.5	1	0.51-2.14	0.91
Overdominant	CT	1.29	0.61-2.76	0.5	1.04	0.51-2.14	0.91

ISSN: 1475-2867