Table 1 Clinicopathological features of high- and low-RPLP2 expression groups in HCC patients
Characteristics | Low expression of RPLP2 | High expression of RPLP2 | P value |
|---|---|---|---|
n | 187 | 187 | |
Age, n (%) | 0.015 | ||
≤ 60 | 77 (20.6%) | 100 (26.8%) | |
> 60 | 110 (29.5%) | 86 (23.1%) | |
Race, n (%) | < 0.001 | ||
Asian | 58 (16%) | 102 (28.2%) | |
Black or African American and White | 124 (34.3%) | 78 (21.5%) | |
Pathologic stage, n (%) | 0.201 | ||
Stage I and stage II | 133 (38%) | 127 (36.3%) | |
Stage III and stage IV | 39 (11.1%) | 51 (14.6%) | |
Pathologic T stage, n (%) | 0.127 | ||
T1 and T2 | 145 (39.1%) | 133 (35.8%) | |
T3 and T4 | 40 (10.8%) | 53 (14.3%) | |
Pathologic N stage, n (%) | 1.000 | ||
N0 | 117 (45.3%) | 137 (53.1%) | |
N1 | 2 (0.8%) | 2 (0.8%) | |
Pathologic M stage, n (%) | 0.777 | ||
M0 | 120 (44.1%) | 148 (54.4%) | |
M1 | 1 (0.4%) | 3 (1.1%) | |
Histologic grade, n (%) | < 0.001 | ||
G1 | 36 (9.8%) | 19 (5.1%) | |
G2 | 102 (27.6%) | 76 (20.6%) | |
G3 | 45 (12.2%) | 79 (21.4%) | |
G4 | 1 (0.3%) | 11 (3%) | |
Histological type, n (%) | 0.007 | ||
Fibrolamellar carcinoma | 3 (0.8%) | 0 (0%) | |
Hepatocellular carcinoma | 184 (49.2%) | 180 (48.1%) | |
Hepatocholangiocarcinoma (mixed) | 0 (0%) | 7 (1.9%) | |
Residual tumor, n (%) | 0.674 | ||
R0 | 165 (47.8%) | 162 (47%) | |
R1 and R2 | 10 (2.9%) | 8 (2.3%) | |
Tumor status, n (%) | 0.020 | ||
Tumor free | 111 (31.3%) | 91 (25.6%) | |
With tumor | 65 (18.3%) | 88 (24.8%) | |
AFP (ng/mL), n (%) | < 0.001 | ||
≤ 400 | 123 (43.9%) | 92 (32.9%) | |
> 400 | 16 (5.7%) | 49 (17.5%) | |
Adjacent hepatic tissue inflammation, n (%) | 0.322 | ||
None | 71 (30%) | 47 (19.8%) | |
Mild | 51 (21.5%) | 50 (21.1%) | |
Severe | 11 (4.6%) | 7 (3%) | |
Vascular invasion, n (%) | 0.180 | ||
No | 111 (34.9%) | 97 (30.5%) | |
Yes | 50 (15.7%) | 60 (18.9%) | |
Albumin(g/dl), n (%) | 0.392 | ||
< 3.5 | 39 (13%) | 30 (10%) | |
≥ 3.5 | 117 (39%) | 114 (38%) | |
OS event, n (%) | 0.002 | ||
Alive | 136 (36.4%) | 108 (28.9%) | |
Dead | 51 (13.6%) | 79 (21.1%) | |
DSS event, n (%) | 0.099 | ||
No | 150 (41%) | 137 (37.4%) | |
Yes | 33 (9%) | 46 (12.6%) | |