Table 1 The role of TRIM21/Ro52 in different cancers and its effect on clinical outcomes

Glioma [15],

Thyroid cancer [16],

Pancreatic cancer [17]

Upregulation of TRIM21/Ro52 would enhanced cancer cell proliferation and drug resistance, resulting in poor overall survival

DLBCL [12],

Renal cell carcinoma [14, 50],

Gastric cancer [41],

ovarian cancer [42],

breast cancer [44,45,46]

Upregulation of TRIM21/Ro52 can suppress tumor proliferation and migration, and increase drug sensitivity, leading to better overall survival