Fig. 6From: Targeting the Endothelin-1 pathway to reduce invasion and chemoresistance in gallbladder cancer cellsPotential use of blocking ET-1 signaling with macitentan in gallbladder cancer therapy. ETRs blockage with macitentan regulates ET-1 target genes expression and nuclear protein levels of β-catenin. ET-1 signaling blockage downregulates EMT markers (Snail and ZEB1), impairing cell invasionBack to article page