Fig. 6From: Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organismCytokines, chemokines, and angiogenesis markers in the liver, spleen, and serum 5 weeks after injecting mice with CHL-1 WT or TPC2 KO melanoma cells. (A) Heatmap representing the overall number of differentially expressed markers in the spleen and liver tissues and serum after injection with CHL-1 WT or TPC2 KO cells. Data in heatmap represents the mean ± s.e.m. of three independent experiments. (B) qPCR validation of representative markers in spleen and liver tissues. Data in bar charts represent the mean ± s.e.m. of three independent experiments (* p < 0.05; ** p < 0.01; *** p < 0.001)Back to article page