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Fig. 3 | Cancer Cell International

Fig. 3

From: DHRS4-AS1 regulate gastric cancer apoptosis and cell proliferation by destabilizing DHX9 and inhibited the association between DHX9 and ILF3

Fig. 3

LncRNA DHRS4-AS1 promotes gastric cancer cell apoptosis and inhibits proliferation in vivo. (A) Tumor size in xenograft mice with tumors derived from Sh-NC-, Sh-DHRS4-AS1#1-, and Sh-DHRS4-AS1#2-expressing AGS cells was evaluated. Data represent the mean ± SD, n = 6. (B) Relative DHRS4-AS1 expression in mouse tumors was evaluated. (C) Vector- and DHRS4-AS1-overexpressing AGS cells were injected into mice. We evaluated tumor growth curves. Data represent the mean ± SD, n = 6. (D) Relative DHRS4-AS1 expression was evaluated in mouse tumors. (E) GC cell apoptosis was analyzed using TUNEL assays using samples from subcutaneously-implanted tumors with different DHRS4-AS1 expression. (F) Immunostaining of apoptosis-related proteins and Ki67 in subcutaneous tumors from DHRS4-AS1-expressing cells. *p < 0.05, **p < 0.01, and ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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